20: <CPU List> IR-IO-APIC 20-fasteoi ohci_hcd:usb9, snd_rme9652, vfio-intx(0000:07:00.0)
So some USB, my passed-through parallel card and my soundcard are all sharing interrupt #20.
And finally you could set the CPU affinity for each interrupt, so at least they're going to be handled by a different CPU than the one that's going to handle the audio interrupt.