I want to play a guitar through Modep LV2 simulators, live.  Is it practical to do this through a USB 3 device (like this https://focusrite.com/en/audio-interface/scarlett/scarlett-solo)?

I am currently using a Pisound on a Raspberry Pi 4, and it is working great.  But it does use up all the gpio pins and I do not need its MIDI facilities.  I would like to be able to use other SBCs, also.

I have used one in the past, over a decade ago, and there was noticeable latency. Have things improved?

Pi Sound and Modep: https://blokas.io/