I have configured Jack from QJackCtl such that the interface I am using is my POD (interface box in the Setup window - interface which is different than the one used in Pulse). Now, I cannot really go on. I guess I have two options to loop my sound back to the speakers (and please correct me if I am wrong): (1) specifying the input and output device in the Setup window appropriately; (2) specifying a proper connection in the Connections window.
Option 1. The Input Device and Output Device scroll down list in the setup window
Yes these are the options that you'll need to use to set up the POD as audio device. Are you sure that ALSA supports the POD device? It seems like there might be a driver issue, as some other Line6 devices require a custom driver to work with Linux: http://sourceforge.net/p/line6linux I hope I'm wrong!
Option 2. The POD appears only in the ALSA tab of the Connection window.
The ALSA tab in QJackCtl shows MIDI devices: the MIDI component of the POD 300 is probably class-compliant (meaning, no special driver required for that part)..