You can have problems if your RAM isn't bigger enough (1 GB or less), because the applications in a 64-bit OS occupes more RAM. 


2013/2/5 david <gnome@hawaii.rr.com>
On 02/04/2013 11:29 PM, James Stone wrote:
Is there any advantage in using a 64 bit distro for audio? Do the
advantages outweigh the difficulties?

I'm expecting a new computer to be delivered today and am trying to
decide what to install...

What difficulties? I run both 32- and 64-bit Linuxes, and have no difficulties with either one.

I can't imagine why anyone would run a 32-bit Linux on a modern processor. Virtually every processor made today is 64-bit. Even the little old dual-core ARM processor in my wife's netbook is 64-bit!

64-bit gives programs access to more on-chip registers, and removes the need for the silly physical address extension (PAE) stuff
.