Apparently there is a proaudio overlay for Gentoo - you probably want to enable that.
Hopefully an actual gentoo user will come and clarify the situation further

On Thu, Oct 29, 2009 at 7:39 AM, Viktor Mastoridis <viktor@mastoridis.co.uk> wrote:
When I start qsynth I get this message:
Qsynth1: Failed to create the audio driver (jack).
Cannot continue without it.
I am running on gentoo (AMD64)
Thanks.

Do you have jack installed and running? On Gentoo jack isn't installed by default and I am not too familiar with Gentoo to get you to do it.

But going down the lane, by your question, I need to ask you the following:
Are you a beginner in the Linux Audio world?
If yes, and you are just starting with Linux audio, I could recommend that you search and try some distros that are maybe easier to handle at the beginning? Like Ubuntu Studio, or AVLinux?

--
Viktor Mastoridis
Music-o-Graph
& Educator
www.MediTera.Co.Uk

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