If you follow back to the start of the thread, I shared some error messages and a link where someone pointed out that the device doesn't follow the USB spec. Not sure of the relevance.
When the sound quits, the computer is generally responsive.
Here's some output about the interrupts. The interface is on Bus 03 / Port 3 / Dev 8 hence xhci_hcd.
antony@cubase:~$ lsusb -t && grep -E "(CPU|xhci)" /proc/interrupts
/: Bus 04.Port 1: Dev 1, Class=root_hub, Driver=xhci_hcd/6p, 5000M
/: Bus 03.Port 1: Dev 1, Class=root_hub, Driver=xhci_hcd/14p, 480M
|__ Port 2: Dev 2, If 0, Class=Mass Storage, Driver=usb-storage, 480M
|__ Port 3: Dev 8, If 0, Class=Audio, Driver=snd-usb-audio, 12M
|__ Port 3: Dev 8, If 1, Class=Audio, Driver=snd-usb-audio, 12M
|__ Port 3: Dev 8, If 2, Class=Audio, Driver=snd-usb-audio, 12M
|__ Port 3: Dev 8, If 4, Class=Application Specific Interface, Driver=, 12M
|__ Port 3: Dev 8, If 6, Class=Audio, Driver=snd-usb-audio, 12M
|__ Port 3: Dev 8, If 7, Class=Audio, Driver=snd-usb-audio, 12M
|__ Port 4: Dev 4, If 0, Class=Video, Driver=uvcvideo, 480M
|__ Port 4: Dev 4, If 1, Class=Video, Driver=uvcvideo, 480M
|__ Port 4: Dev 4, If 2, Class=Audio, Driver=snd-usb-audio, 480M
|__ Port 4: Dev 4, If 3, Class=Audio, Driver=snd-usb-audio, 480M
|__ Port 7: Dev 5, If 0, Class=Human Interface Device, Driver=usbhid, 1.5M
|__ Port 8: Dev 6, If 0, Class=Human Interface Device, Driver=usbhid, 1.5M
|__ Port 8: Dev 6, If 1, Class=Human Interface Device, Driver=usbhid, 1.5M
/: Bus 02.Port 1: Dev 1, Class=root_hub, Driver=ehci-pci/2p, 480M
|__ Port 1: Dev 2, If 0, Class=Hub, Driver=hub/8p, 480M
/: Bus 01.Port 1: Dev 1, Class=root_hub, Driver=ehci-pci/2p, 480M
|__ Port 1: Dev 2, If 0, Class=Hub, Driver=hub/6p, 480M
CPU0 CPU1 CPU2 CPU3
29: 1488 1092584730 0 0 IR-PCI-MSI 327680-edge xhci_hcd
Nothing else is using that USB port.
Whilst reading around the points you raised, I found irqbalance. I see it is installed by default and running (not sure if that's a good thing, it sounds like a good idea to balance interrupts across all cores).
I don't have a Mac or Windows machine to test with.