is it a 1st Gen or 2nd Gen?
I've got a 18i20 2nd Gen, -n 2 -p 128 works with my outdated Athlon
and now with my Celeron without issues. IOW even my new machine hasn't
got much horsepower.
If irqbalance should be enabled, disable it.
Did you already test
different USB ports?
What's the output of
/path/to/rtirq status
What kernel are you using?
uname -a