Hey Diego!
NON is generally a nice approach. The problem I had with it, as far as I remember, is that it does not support MIDI. Which really kills the whole deal for me, since the rest of Linux Audio apps are MIDI apps. Somewhere on the NON site there was a lengthy instruction on how to setup a bridge between MIDI and OSC, but that was not my cup of tea, that kind of tech voodoo.
The power of Linux Audio - the diversity of solutions - is at the same time its weakness, as typically your setup at any given time will reliably have apps that fall out of your routine. Currently for me it is seq24 that does not work with JACK Transport. If this is going to be fixed someday, by that time some other app might have another problem. At the same time seq24 has no reliable automation (I was told it is there, I found nothing, tbh). And also seq24 has weird volume editing.
As mentioned with NON, it does not support MIDI. Ardour 3 works great, but does not support DSSI, so no WhySynth or Nekobee, for instance.