i really recommend pyseq and midikinesis by peter brinkmann... you can find it here: http://www.math.tu-berlin.de/~brinkman/software/ after playing around in python interactive shell (actually ipython for me) for a bit i got note playing in fluidsynth.. this is how it looked like: 1 : import pyseq 2 : seq = pyseq.MidiTee('miditi') ## after this you can find miditi with aconnect -lo or -li or better qjackctl.. connect it with fluidsynth or some other synth and then: 3 : e=pyseq.snd_seq_event() 4 : e.setNoteOn(0, 60, 127) 5 : seq.callback(e) this was way easier than anything else i ever tried... i dunno if this is the right way to do that but i just feel to say: all kudos to brinkman ;)