Marco Milanesi wrote: Hi Marco, I've cc'd this response to the lists because I want to clarify the situation for all who are interested. The short answer is, "Yes". The longer answer is "Yes, with some very specific caveats." Wine can be compiled as a 32-bit binary for running in a pure 64-bit system. I'm running such an arrangement now, with backport packages of Wine and libwine 0.9.34 (Debian, 64 Studio). However, IIRC 64 Studio already has more recent packages available. The biggest problem is latency. In this scenario it's not possible to use the JACK/wineasio combination, so you'll end up using either the OSS or ALSA sound system for Wine (select in winecfg). It may be possible to lower latency with either of those drivers, but I've not worked at it. So far I've only tested Reaper with some VST plugs. It worked, but I wouldn't try using it as a production environment. I haven't yet tested any other hosts. And just to be clear: At this time I would advise anyone who wants to run VST plugins in production to do so with either JAD or 32-bit 64 Studio. They support the wineasio driver, thus greatly improving the latency numbers. Best, dp