Hello Jeremy!
Oh bugger, I would have suggested Ecasound/Nama as your first options. :-)
but there is csound, although I have a feeling, that it's LADSPA support can
be a little confusing not to say buggy. No idea, what the current state is, I
tried it last over a year ago.
Perhaps CLM has LADSPA/DSSI support as well.
But I'm really wondering, why Ecasound should use so much CPU power. Yes it
does like to start two instances of plugns. I'm not sure how it behaves
exactly, when there's a discrepancy between inputs and outputs. but running it
in Ecasound would have a few advantages: MIDI controllability from the
outside, a stable and well-behaved host.
I had been looking, but didn't find it. But I'm sure, that either in
relation to the sndfile-suite or in the neighbourhood of jack-dssi-host there
had been another small utility to run LADSPA plugins. Sorry I can't be more
specific.
At least sox can handle ADSPA. But sox to my knowledge has no JACK support.
I hope some of this may be of help to you.
Good luck
Julien
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http://juliencoder.de/nama/music.html