[LAU] noise problem, need some help

Greetings, Recently my computer rebooted after a power outage and after having an uptime of many months. I'm running Fedora 23 here, with Fernando's rt kernel from Planet CCRMA, on hardware that includes an AMD FX6300, 16G memory, a big hard drive, and nVidia graphics. For those months of uptime I've enjoyed a smooth-running system with very few issues. The CPU runs in performance mode, and as far as I can tell the system has been sweetly optimized for realtime audio. Alas, after rebooting I now have extremely annoying issues with noise from my wireless mouse when running VCV Rack, which is a problem I never had before the reboot. I suspect IRQ assignment, but I'm awfully rusty at troubleshooting so I'm asking the group for advice. My checklist so far: 1. Running the correct kernel ? Linux The6300 4.6.7-200.rt14.1.fc23.ccrma.x86_64+rt #1 SMP PREEMPT RT Sat Oct 1 16:06:12 PDT 2016 x86_64 x86_64 x86_64 GNU/Linux 2. CPU in Performance mode ? 'cat /proc/cpuinfo' reports 'cpu MHz: 3500.000' for all cores 3. rtprio set ? $ rtirq status PID CLS RTPRIO NI PRI %CPU STAT COMMAND 169 FF 70 - 110 0.0 S irq/8-rtc0 748 FF 69 - 109 0.0 S irq/19-snd_hda_ 764 FF 69 - 109 2.0 S irq/20-snd_ice1 166 FF 68 - 108 0.0 S irq/1-i8042 85 FF 50 - 90 0.0 S irq/9-acpi 138 FF 50 - 90 0.0 S irq/22-ahci[000 150 FF 50 - 90 0.0 S irq/17-ehci_hcd 151 FF 50 - 90 0.0 S irq/19-ehci_hcd 153 FF 50 - 90 0.0 S irq/16-ohci_hcd 154 FF 50 - 90 0.0 S irq/16-ohci_hcd 155 FF 50 - 90 0.0 S irq/18-ohci_hcd 156 FF 50 - 90 0.0 S irq/18-ohci_hcd 159 FF 50 - 90 0.0 S irq/18-ohci_hcd 430 FF 50 - 90 0.0 S irq/14-pata_ati 431 FF 50 - 90 0.0 S irq/15-pata_ati 706 FF 50 - 90 0.0 S irq/7-parport0 1062 FF 50 - 90 0.0 S irq/26-enp2s0 1178 FF 50 - 90 0.8 S irq/27-nvidia ... Permissions are correct, and I have already tried switching the wireless dongle to a different USB port. So what am I missing, what have I forgotten ? The machine is the same as before the reboot, the kernel is the same, and as far as I can tell the audio system is the same as it ever was. I'm at a bit of a loss here, any and all help will be appreciated. Best regards, dp