Even though the P67 and H67 do not support the PCI bus natively, PCI is accessd through a PCI - PCI-e Bridge. If you look at page 8 in the manual you'll see there's a little bridge chip between the south bridge and the PCI slots. PCI slots have been running through these bridge chips for a while now, this doesn't appear to be the issue. It appears as though some of the settings are getting changed but audio isn't passing, it may be possible that there are other on-board devices bound to the PCI slot where the Delta 44 card is plugged into. There may be 16 IRQ's however as indicated on page 11 of the manual there are more than 16 devices on that motherboard, so the system will share devices on the same IRQ. I would suggest disabling devices that are bound to the PCI slot in the BIOS to see if that frees up enough bandwidth for the card to operate. Unfortunately Gigabyte does not include an IRQ sharing matrix like ASUS does, however if you refer back to page 8 to the block diagram you can see on the left side of the diagram which devices are sharing with the PCI slots. There you will see a single line for a PCI Express bus, dropping down to the bottom is the ITE Bridge chip which goes to the PCI slots, however on the same line dropping down you'll see the Network Controller is on there and on the top of that line are all the other PCI-e slots except for the primary PCI-e x16 slot which is running off of the NorthBridge. At this point you'll need to do some experimentation with pulling any other cards you have in your system that is not the primary graphics controller. If you're running dual graphics cards, try removing one out of the second PCI-e x16 slot to see if that changes anything.Also if you have any PCI-e x4 or x1 cards you should remove them just to see if that helps to narrow your search. Also, typically USB ports are also bound to PCI slots for power management. If you have something plugged into the USB ports that take up a lot bandwidth (ie hard drives, cameras, scanners) these will cause a card like the Delta 44 to malfunction. Try toggling settings on and off to see if that changes the behavior of the Delta card. Why is this all necessary? The Delta 44 was developed back in 1999!! before all this newer technology came out that surrounds it. The Delta is a bus mastering card which requires full bandwidth of the slot, anything that takes away from that requirement will cause the card to not operate properly, so it doesn't play well with power management schemes. Also this motherboard has a ton of features for power management, consider turning that off too temporarily to see if that changes the situation too. It also doesn't hurt to see if Gigabyte has an updated BIOS release providing improved PCI performance. Try that and see if anything improves.